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ONECUT1

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Horizontal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, Hep G2, MCF7, NTERA-2, SuSa, WM-115)

Interaction

Binds DNA as a monomer.

Molecular function

Activator, DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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