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P2RX4
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene.
Protein class
FDA approved drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Distal enterocytes, Hofbauer cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with P2X7 (via C-terminus); this interaction is functional only in the presence of ATP (PubMed:26456657). Interacts with AP1M2 (By similarity).
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
More Types Infomation
- Human Anti-P2RX4 Recombinant Antibody; scFv Fragment (TAB-0914CL-S(P)) (TAB-0914CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Rat Anti-P2rx4 Recombinant Antibody; scFv Fragment (TAB-0915CL-S(P)) (TAB-0915CL-S(P))
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- Species Reactivity: Mouse
- Type: Rat scFv
- Application: ELISA
- Human Anti-P2RX4 Recombinant Antibody (TAB-0914CL) (TAB-0914CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Rat Anti-P2rx4 Recombinant Antibody (TAB-0915CL) (TAB-0915CL)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: ELISA
- Human Anti-P2RX4 Recombinant Antibody; Fab Fragment (TAB-0914CL-F(E)) (TAB-0914CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Rat Anti-P2rx4 Recombinant Antibody; Fab Fragment (TAB-0915CL-F(E)) (TAB-0915CL-F(E))
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- Species Reactivity: Mouse
- Type: Rat Fab
- Application: ELISA
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For Research Use Only. Not For Clinical Use.