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PAG1
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal enterocytes, Microglial cells, Melanocytes, Sertoli cells, granulocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HMC-1, SK-MEL-30)
Interaction
Interacts with FYN. When phosphorylated, interacts with CSK. Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Interacts with LYN on plasma membrane lipid rafts. Identified in a complex with LYN and STAT3.
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P, IP, FC
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For Research Use Only. Not For Clinical Use.