Enzymes, FDA approved drug targets, Metabolic proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3 (By similarity). Homo- and heterodimer with PARP1 (PubMed:20092359). Interacts (via the PARP catalytic domain) with HPF1 (PubMed:27067600, PubMed:28190768, PubMed:32028527, PubMed:32939087, PubMed:33141820). Interacts with core nucleosomes (PubMed:32939087, PubMed:33141820).
DNA-binding, Glycosyltransferase, Transferase
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For Research Use Only. Not For Clinical Use.