Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Microglial cells, Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Astrocytes)
Low immune cell specificity
Cell line enhanced (RPTEC TERT1, SCLC-21H, U-937)
The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits (PubMed:6765947, PubMed:20725044). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705). Interacts with SIRT3 and SIRT5 (PubMed:23438705).
Ligase
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For Research Use Only. Not For Clinical Use.