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PCDH11Y

This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Protein class

Disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons, Horizontal cells, Alveolar cells type 2)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Interacts with CTNNB1.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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