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PCDHGA5

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Bipolar cells, Horizontal cells, Endometrial stromal cells, Sertoli cells, Skeletal myocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (ASC diff, ASC TERT1)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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