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PCK1

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
PCK1
Protein class

Citric acid cycle related proteins, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Proximal enterocytes, Hepatocytes, Distal enterocytes, Distal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (ASC diff)

Interaction

Monomer.

Molecular function

Decarboxylase, Kinase, Lyase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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