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PDE3A
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Astrocytes, Inhibitory neurons, Horizontal cells, Smooth muscle cells, Bipolar cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, HEL, HeLa, HUVEC TERT2, SH-SY5Y, U-138 MG)
Interaction
Homodimer (PubMed:8155697, PubMed:34272366). Interacts with SLFN12; direct low affinity interaction which is stimulated by binding of 17beta-estradiol/E2 to PDE3A and that positively regulates the ribonuclease activity of SLFN12 (PubMed:31420216, PubMed:35104454, PubMed:34272366, PubMed:34707099).
Molecular function
Hydrolase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.