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PDK1
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Plasma cells, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-266/70, U-87 MG)
Interaction
Homodimer, and heterodimer with PDK2. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).
Molecular function
Kinase, Transferase
More Types Infomation
Related Diseases
Endometrial Cancer
Non-small Cell Lung Cancer
Prostate Cancer
Insulin Resistance
Related Signaling Pathways
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
PPAR Signaling Pathway
Ras Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FC, ICC/IF, IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
- Mouse Anti-PDK1 Recombinant Antibody (clone 4A11) (VS3-XY1232)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
- Human Anti-PDK1 Recombinant Antibody (clone 2B9); Fab Fragment (HPAB-0015-CN-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: IF, ELISA, FC
- Human Anti-PDK1 Recombinant Antibody (clone 2B9) (HPAB-0015-CN)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: IF, ELISA, FC
- Human Anti-PDK1 Recombinant Antibody (clone 2B9); scFv Fragment (HPAB-0015-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: IF, ELISA, FC
- Rabbit Anti-PDK1 Recombinant Antibody (VS3-WK1313) (VS3-WK1313)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse
- Type: Rabbit IgG
- Application: ELISA, IHC, WB
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For Research Use Only. Not For Clinical Use.