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PHLDA2

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Urothelial cells, Extravillous trophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HDLM-2, PC-3, SK-MEL-30, WM-115)

More Types Infomation

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