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PIGR
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Distal enterocytes, Undifferentiated cells, Paneth cells, Intestinal goblet cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (EFO-21)
Interaction
Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357). Interacts (mainly via CDR2-like domain) with pentameric IgM (PubMed:10229845). [Secretory component]: Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:8292260, PubMed:19079336, PubMed:32029686, PubMed:16543244). Free secretory component interacts with bacterial antigens toxA of C. difficile and eae of E. coli (PubMed:16543244).
More Types Infomation
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- Species Reactivity: Mouse
- Type: IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P
- Mouse Anti-PIGR Recombinant Antibody (clone 3C8) (MOB-2531z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
- Camelid Anti-PIGR Recombinant Antibody (clone 1E7) (HPAB-0924-YJ)
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- Derivation: Llama
- Type: Camelid VHH
- Application: ELISA, Antagonist, IF
- Camelid Anti-PIGR Recombinant Antibody (clone 1D2) (HPAB-0923-YJ)
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- Derivation: Llama
- Type: Camelid VHH
- Application: ELISA, Antagonist, IF, IP, Transcytosis capacity
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For Research Use Only. Not For Clinical Use.