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PKD2

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Protein class

Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Microglial cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166)

Interaction

Homotetramer (PubMed:20881056, 27768895, 27991905, 28092368, 29899465). Heterotetramer with PKD1, giving rise to a complex formed by one PKD1 chain and three PKD2 chains (PubMed:20881056, 19556541, 27214281, 30093605). Interaction with PKD1 is required for ciliary localization (By similarity) Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). Interacts with PKD1L1. Interacts with CD2AP (PubMed:10913159). Interacts with HAX1 (PubMed:10760273). Interacts with NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts (via C-terminus) with TRPV4 (via C-terminus) (PubMed:18695040). Interacts (via C-terminal acidic region) with PACS1 and PACS2; these interactions retain the protein in the endoplasmic reticulum and prevent trafficking to the cell membrane (PubMed:15692563). Interacts with TMEM33 (By similarity).

Molecular function

Calcium channel, Ion channel, Potassium channel, Voltage-gated channel

More Types Infomation

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