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PKP1
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, PC-3)
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Human
- Type: IgG
- Application: WB, ICC/IF, FC
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, IP, WB
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- Species Reactivity: Mouse, Human
- Type: Mouse IgG1
- Application: IHC-P, IHC-Fr, WB, IP
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For Research Use Only. Not For Clinical Use.