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PLP1

A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of integrin alphav-beta3 complex. Used to study demyelinating disease and visual epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
Protein class

Cancer-related genes, Disease related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Oligodendrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (SK-MEL-30, WM-115)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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