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PLS1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5 UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal enterocytes, Proximal enterocytes, Paneth cells, Intestinal goblet cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A-431, BEWO, OE19, RPTEC TERT1)

Interaction

Monomer.

Molecular function

Actin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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