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POGZ
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Protein class
Disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts (via IBM motif) with PSIP1 isoform 1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:19244240, 25082813, 29997176). Interacts with HDGFL2 (PubMed:26721387).
Molecular function
DNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P, FC, ICC/IF
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For Research Use Only. Not For Clinical Use.