Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Intracellular
Cell type enhanced (Spermatocytes)
Low immune cell specificity
Cell line enhanced (U-698)
Interacts with REV1 (By similarity). Interacts with monoubiquitinated PCNA, but not unmodified PCNA (PubMed:15149598). Interacts with POLI; this interaction targets POLI to the replication machinery (PubMed:12606586). Interacts with PALB2 and BRCA2; the interactions are direct and are required to sustain the recruitment of POLH at blocked replication forks and to stimulate POLH-dependent DNA synthesis on D loop substrates (PubMed:24485656). Interacts (via C-terminus) with TRAIP (PubMed:24553286). Interacts with ubiquitin (PubMed:16357261). Interacts with POLDIP2 (PubMed:20554254).
DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
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For Research Use Only. Not For Clinical Use.