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PON1

Serum paraoxonase and aryl esterase 1 (PON1), also known as A esterase, homocysteine thiolactamase or serum aryl dialkyl phosphatase 1, are enzymes encoded by the PON1 gene in the human body. Paraoxonase 1 has esterase, especially paraoxonase activity. PON1 is responsible for the hydrolysis of organophosphate pesticides and neurotoxic gases. The polymorphism of PON1 gene significantly affects the catalytic ability of this enzyme. PON1 (paraoxonase 1) is also the main anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, thereby increasing the synthesis and release of paraoxonase 1 enzyme from the liver and reducing atherosclerosis.
PON1
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Transporters

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Hepatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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