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POU2F2
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (B-cells, monocytes, Kupffer cells, Macrophages, Langerhans cells, Plasma cells, Spermatocytes)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enhanced (BJ hTERT+, Daudi, hTEC/SVTERT24-B, U-266/70, U-266/84, U-698, U-87 MG)
Interaction
Interacts with NR3C1, AR and PGR (PubMed:10480874). Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity (PubMed:7859290).
Molecular function
Activator, DNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, IHC-P, WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC-P
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.