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POU5F1
The protein encoded by this gene belongs to the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein plays a key role in embryonic development and stem cell pluripotency. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SuSa)
Interaction
Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (By similarity). Interacts with ZNF322 (By similarity). Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355 (By similarity). Interacts (when phosphorylated on Ser-355) with FBXW8 (By similarity). Interacts with FBXW4 (By similarity). Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity).
Molecular function
Developmental protein, DNA-binding
More Types Infomation
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IF
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, ChIP
- Rabbit Anti-POU5F1 Polyclonal Antibody (MRO-2092-CN) (MRO-2092-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IP, IHC, ELISA
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, IHC-P, IP, WB
- Rabbit Anti-POU5F1 Recombinant Antibody (clone AFY0036) (MOR-0065-FY)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, WB
- Recombinant Mouse Anti-POU5F1 Antibody (VS-0923-FY125) (VS-0923-FY125)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
- Recombinant Mouse Anti-POU5F1 Antibody (clone 3C1F5) (VS3-FY1173)
-
- Type: Mouse IgG1
- Application: ELISA, IHC, FC
- Mouse Anti-POU5F1 Recombinant Antibody (clone 7E7) (VS3-XY1282)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, ICC
- Mouse Anti-POU5F1 Recombinant Antibody (clone 5F7) (VS3-XY1281)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Mouse Anti-POU5F1 Recombinant Antibody (clone 3A5) (VS3-XY1280)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Recombinant Mouse Anti-POU5F1 Antibody (clone 2D9H4) (VS3-FY1172)
-
- Type: Mouse IgG1
- Application: ELISA, ICC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.