Metabolic proteins
Intracellular
Cell type enhanced (Granulosa cells, Theca cells, Excitatory neurons, Erythroid cells)
Not detected in immune cells
Cell line enhanced (AN3-CA, Daudi, K-562, U-698)
The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with PRKACA and PRKACB (PubMed:33058759). Interacts with the phosphorylated form of PJA2. Forms a complex composed of PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:25920809).
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For Research Use Only. Not For Clinical Use.