Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Late spermatids)
Low immune cell specificity
Low cell line specificity
Homodimer. Interacts with EIF2AK2/PKR through its DRBM domains. Interacts with DICER1, AGO2 and TARBP2. Also able to interact with dsRNA. Interacts with UBC9 (By similarity). Forms a complex with UBC9 and p53/TP53 (By similarity). Interacts with DUS2L (via DRBM domain). Interacts with DDX58. (Microbial infection) Interacts with ebolavirus protein VP35; this interaction inhibits the interaction between DDX58 and PRKRA. In addition, this interaction disrupts the interaction between VP35 and the viral polymerase L. So the VP35-PRKRA interaction plays a critical role in determining the outcome of ebolavirus infection (PubMed:23870315). The interaction PRKRA-VP35 also prevents PRKRA binding to DICER1 and thus allows the virus to counteract host RNA silencing (PubMed:21228243).
RNA-binding
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For Research Use Only. Not For Clinical Use.