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PRPF8
mRNA preprocessing splicing factor 8 is a protein encoded by the PRPF8 gene in humans.
Pre-mRNA splicing occurs in two consecutive transesterification steps. The protein encoded by this gene is an integral part of U2 and U12 dependent spliceosomes, and was found to be essential for catalytic step II in the pre-mRNA splicing process. It contains several WD repeat sequences that interact between proteins. This protein has sequence similarity with yeast Prp8 protein. This gene is a candidate gene for autosomal dominant hereditary retinitis pigmentosa.
Pre-mRNA splicing occurs in two consecutive transesterification steps. The protein encoded by this gene is an integral part of U2 and U12 dependent spliceosomes, and was found to be essential for catalytic step II in the pre-mRNA splicing process. It contains several WD repeat sequences that interact between proteins. This protein has sequence similarity with yeast Prp8 protein. This gene is a candidate gene for autosomal dominant hereditary retinitis pigmentosa.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of the U5 snRNP complex (PubMed:2532307, 2527369). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:2479028, 16723661, 26912367). Component of the U5. U4atac/U6atac snRNP complexes in U12-dependent spliceosomes (PubMed:11971955). Core component of U2-type precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:10411133, 28502770, 28781166, 28076346, 29361316, 30315277, 29360106, 29301961, 30728453, 30705154). Found in a mRNA splicing-dependent exon junction complex (EJC) with SRRM1. Interacts with U5 snRNP proteins SNRP116 and SNRNP40. Interacts with EFTUD2 and SNRNP200. Interacts (via the MPN (JAB/Mov34) domain) with PRPF3 ('Lys-63'-linked polyubiquitinated); may stabilize the U4/U6-U5 tri-snRNP complex. Interacts (via RNase H homology domain) with AAR2 (PubMed:26527271). Interacts with RPAP3 and URI1 in a ZNHIT2-dependent manner (PubMed:28561026).
Molecular function
Ribonucleoprotein, RNA-binding
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Application: Dot, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.