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PRSS8
Prostasin is a protein that in humans is encoded by the PRSS8 gene, which possesses a trypsin-like cleavage specificity with a preference for polybasic substrates and stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Protein class
Enzymes
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Distal enterocytes, Proximal enterocytes, Paneth cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2, CAPAN-2, hTCEpi, OE19, SK-BR-3)
Interaction
Heterodimer of two chains, light and heavy, held by a disulfide bond.
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
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- Species Reactivity: Human
- Type: IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.