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PSMB10
This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive beta subunits with inducible beta subunits which possess specific cleavage properties that aid in the release of peptides necessary for MHC class I antigen presentation.
Protein class
Enzymes, FDA approved drug targets, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (REH, RPMI-8226, THP-1, U-266/70)
Interaction
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB7. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. (Microbial infection) Interacts with HIV-1 TAT protein.
Molecular function
Hydrolase, Protease, Threonine protease
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P, FC
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IF
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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For Research Use Only. Not For Clinical Use.