Disease related genes, Enzymes, Plasma proteins, Potential drug targets
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 9344905, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 9344905, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 9344905, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 9344905, 34711951). Forms a ternary complex with SMAD1 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (PubMed:11571290, 12097147). Interacts with PRPF19 (PubMed:15660529). (Microbial infection) Interacts with HTLV-1 Tax protein. (Microbial infection) Interacts with HIV-1 Nef and Tat proteins.
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For Research Use Only. Not For Clinical Use.