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PSMB5
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
Protein class
Enzymes, FDA approved drug targets, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Hep G2)
Interaction
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 8163024, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 8163024, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 8163024, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 8163024, 34711951). Directly interacts with POMP (PubMed:15944226). Interacts with ABCB1 and TAP1 (PubMed:15488952). (Microbial infection) Interacts with HIV-1 TAT protein.
Molecular function
Hydrolase, Protease, Threonine protease
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IHC, IF
- Recombinant Anti-Human PSMB5 Antibody scFv Fragment (MOB-3043z-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, IF, FuncS
- Recombinant Anti-Human PSMB5 Antibody Fab Fragment (MOB-3043z-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, WB, FuncS
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For Research Use Only. Not For Clinical Use.