Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (NK-cells, Theca cells, T-cells, Enteroendocrine cells, dendritic cells, monocytes, Hofbauer cells, Kupffer cells, Macrophages)
Low immune cell specificity
Cell line enhanced (HDLM-2, HL-60, NB-4, THP-1, U-937)
Homodimer (PubMed:19584923). Homotrimer (PubMed:17964261). Interacts (via coiled-coil domain) with CD2AP, PTPN12 and PTPN18. Interacts (via SH3 domain) with ABL1 and WAS. Interacts (via SH3 and coiled-coil domains) with MEFV (via B-box zinc finger); the interaction allows binding of MEFV to PYCARD and facilitates formation of PYCARD pyroptosomes. Interacts with CD2, DNM2 and FASLG.
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For Research Use Only. Not For Clinical Use.