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PTGIS

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Peritubular cells, Fibroblasts, Endothelial cells, Leydig cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (ASC diff, ASC TERT1, U-2197)

Molecular function

Isomerase, Lyase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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