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PTPRN

PTPRN (Protein Tyrosine Phosphatase Receptor Type N) is a Protein Coding gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Diseases associated with PTPRN include Insulinoma and Type 1 Diabetes Mellitus.
Protein class

Disease related genes, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Horizontal cells, Cone photoreceptor cells, Bipolar cells, Inhibitory neurons, Enteroendocrine cells, Excitatory neurons, Rod photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (U-2 OS, U-87 MG)

Interaction

Homodimer; shown for the unprocessed protein (proICA512) in the endoplasmic reticulum and resolved during protein maturation as ICA512-TMF seems to be predominantly monomeric in secretory granules; however, ICA512-CCF interacts with ICA512-TMF disrupting the ICA512-TMF:SNTB2 complex. The isolated lumenal RESP18 homology domain has been shown to form disulfide-linked homooligomers (PubMed:25561468, 18824546, 26836020). Interacts (via cytoplasmic domain) with phosphorylated SNTB2; this protects PTPRN against cleavage by CAPN1 to produce ICA512-CCF. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in PTPRN cleavage (PubMed:11483505). Interacts with SNX19 (PubMed:16273344). ICA512-CCF interacts with PIAS4; in the nucleus (PubMed:15596545). Interacts with STAT5B (phosphorylated); down-regulated by ICA512-CCF sumoylation; ICA512-CCF prevents STAT5B dephosphorylation; ICA512-CCF mediates interaction of STAT5B with PIAS4 (PubMed:15596545, 16622421). Interacts (via RESP18 homology domain) with insulin and proinsulin (PubMed:26836020). Interacts with PTPRN2, PTPRA and PTPRE (By similarity).

Molecular function

Receptor

More Types Infomation

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