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PURA
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1. Interacts with FMR1; this interaction occurs in association with polyribosome.
Molecular function
Activator, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, ICC, WB
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For Research Use Only. Not For Clinical Use.