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PYGB
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
Protein class
Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal enterocytes, Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (PC-3, SK-MEL-30)
Interaction
Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Molecular function
Allosteric enzyme, Glycosyltransferase, Transferase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IA, WB
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For Research Use Only. Not For Clinical Use.