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RACGAP1
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Erythroid cells, Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Associates with alpha-, beta- and gamma-tubulin and microtubules. Interacts via its Rho-GAP domain with RND2. Associates with AURKB during M phase. Interacts via its Rho-GAP domain and basic region with PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts with SLC26A8 via its N-terminus. Interacts with RAB11FIP3. Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a microtubule-dependent manner, is enhanced by phosphorylation by PLK1 and phosphorylation at Ser-164 plays a major role in mediating binding (PubMed:25068414). Interacts with KIF23; the interaction is direct.
Molecular function
Developmental protein, GTPase activation
More Types Infomation
- APC-B*07:02/Human RACGAP1 (LPQANRDTL) MHC Tetramer (MHC-LC2105)
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- Class: Class I
- Antigen: RACGAP1
- Antigen Species: Human
- Peptide: LPQANRDTL
- Conjugate: APC
- PE-B*07:02/Human RACGAP1 (LPQANRDTL) MHC Tetramer (MHC-LC2104)
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- Class: Class I
- Antigen: RACGAP1
- Antigen Species: Human
- Peptide: LPQANRDTL
- Conjugate: PE
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
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For Research Use Only. Not For Clinical Use.