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RAD54L

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Extravillous trophoblasts, Glandular and luminal cells, Erythroid cells)

Immune cell specificity

Immune cell enhanced (T-reg)

Cell line specificity

Low cell line specificity

Interaction

Homohexamer (By similarity). Interacts (via N-terminus) with RAD51 (PubMed:9321665). Interacts with NAP1L1 (PubMed:24798879). Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation (PubMed:32457312).

Molecular function

DNA-binding, Helicase, Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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