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RASGRP3
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
Protein class
RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Urothelial cells, Plasma cells)
Immune cell specificity
Group enriched (naive B-cell, basophil, memory B-cell)
Cell line specificity
Group enriched (Daudi, HEL, U-266/70, U-266/84, U-698)
Molecular function
Guanine-nucleotide releasing factor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC/IF
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For Research Use Only. Not For Clinical Use.