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RASSF1
Ras association domain family member 1 (RASSF1) is a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Protein class
Human disease related genes, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (dendritic cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with MAP1S (PubMed:15205320, PubMed:15753381). Interacts with XPA (PubMed:10888881). Binds to the N-terminal of CDC20 during prometaphase (PubMed:14743218). Binds to STK3/MST2 and STK4/MST1 (PubMed:15109305, PubMed:16510573, PubMed:21199877). Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (PubMed:15949439). Can self-associate (PubMed:11857081). Part of a complex with MDM2, DAXX, RASSF1 and USP7 (PubMed:18566590). Interacts with ECM2 (By similarity). [Isoform A]: Interacts with MOAP1 (PubMed:15949439). Interacts with E4F1 (PubMed:14729613). Interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer (PubMed:11857081). Interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53 (PubMed:18566590). Interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53 (PubMed:18566590). Interacts with RAB39A (By similarity). Interacts with RAB39B; the interaction is weak (By similarity). [Isoform C]: Interacts (via N-terminus) with DAXX (PubMed:18566590). Interacts with RAB39B; the interaction is strong (By similarity). Does not interact with RAB39A (By similarity). [Isoform H]: Interacts (via N-terminus) with DAXX.
More Types Infomation
Related Diseases
Bladder Cancer
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- Species Reactivity: Human
- Application: IP, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.