RBCK1

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Intracellular

Low cell type specificity

Low immune cell specificity

Cell line enhanced (hTCEpi)

Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31 (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:28481331, PubMed:22430200). LUBAC has a MW of approximately 600 kDa suggesting a heteromultimeric assembly of its subunits (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) (By similarity). Interacts with UBE2L3 (By similarity). Interacts with PRKCH (PubMed:9195957). Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner (PubMed:20005846). Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1 (PubMed:17449468). Interacts with IRF3 (PubMed:18711448). [Isoform 1]: Interacts with IREB2 only in iron-rich conditions. [Isoform 2]: Interacts with IREB2 only in iron-rich conditions. (Microbial infection) Interacts with S. flexneri E3 ubiquitin-protein ligases IpaH1. 4 and IpaH2. 5, leading to its ubiquitination. (Microbial infection) Interacts with hepatitis B virus/HBV protein HBx; this interaction is required to activate transcription of the viral genome.

Transferase