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RBL2
Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with AATF. Interacts with KMT5B, KMT5C and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5). Interacts with RBBP9 (By similarity). (Microbial infection) Interacts with JC virus small t antigen.
Molecular function
Chromatin regulator, DNA-binding, Repressor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IP, WB
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- Species Reactivity: Human
- Application: IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC
- Mouse Anti-RBL2 Recombinant Antibody (clone 8C11H5) (VS3-XY1364)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
- Mouse Anti-RBL2 Recombinant Antibody (clone 2C8A8) (VS3-XY1363)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.