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RBPJ
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA1/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Interacts with SNW1. Interacts with CHCHD2 and CXXC5 (PubMed:23303788). Interacts with BEND6 (via BEN domain). Interacts with NKAPL (By similarity). Interacts with ZMIZ1. Interacts with RBM15 (By similarity).
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, IF, WB, FC
-
- Species Reactivity: Human
- Application: WB
-
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF
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- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.