Disease related genes, Human disease related genes
Intracellular
Group enriched (Cone photoreceptor cells, Bipolar cells, Rod photoreceptor cells)
Not detected in immune cells
Cell line enhanced (HEL, HMC-1, SH-SY5Y)
Monomer (PubMed:30559291). Interacts with GUCY2D; negatively regulates its activity (PubMed:21928830, PubMed:26100624, PubMed:27471269, PubMed:30559291). The interaction with GUCY2D promotes the exit of GUCY2D from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21078983). Interacts with GUCY2F (By similarity). The interaction with GUCY2F negatively regulates GUCY2F activity (PubMed:29515371). The interaction with GUCY2F promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21078983). Interacts with GUK1; up-regulates GUK1 activity (PubMed:29515371).
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For Research Use Only. Not For Clinical Use.