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RERE

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Low cell line specificity

Interaction

Interacts with HDAC1 (By similarity). Interacts with ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended. Interacts with FAT1.

Molecular function

Developmental protein, Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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