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REV3L
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Endometrial stromal cells, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.
Molecular function
DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
More Types Infomation
- Recombinant Anti-Human REV3L Antibody (MOB-3418z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Dot, FuncS
- Recombinant Anti-Human REV3L Antibody scFv Fragment (MOB-3418z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-Human REV3L Antibody Fab Fragment (MOB-3418z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FacS, FuncS
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For Research Use Only. Not For Clinical Use.