Plasma proteins
Intracellular
Cell type enhanced (Spermatocytes, Extravillous trophoblasts, Spermatogonia)
Low immune cell specificity
Low cell line specificity
Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. Interacts with CNTD1; this interaction facilitates crossover formation (By similarity).
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For Research Use Only. Not For Clinical Use.