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RGS9
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Rod photoreceptor cells, Cone photoreceptor cells)
Immune cell specificity
Group enriched (gdT-cell, memory CD8 T-cell, NK-cell, naive CD8 T-cell, MAIT T-cell)
Cell line specificity
Cell line enhanced (HDLM-2, HEL, hTERT-RPE1, SuSa)
Interaction
Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.
Molecular function
Signal transduction inhibitor
More Types Infomation
Related Diseases
Cocaine Addiction
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, ICC, FC
- Chicken Anti-RGS9 Polyclonal IgY (BRD-0509MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.