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RIMS2
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis.
Protein class
Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Rod photoreceptor cells, Cone photoreceptor cells, Oligodendrocyte precursor cells, Bipolar cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Daudi, RT4, SCLC-21H, SuSa, U-2 OS)
Interaction
Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 (By similarity).
More Types Infomation
- Recombinant Mouse Anti-Human RIMS2 Antibody (MOB-1651MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
- Mouse Anti-RIMS2 Recombinant Antibody (clone 3G2) (VS3-XY1373)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.