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RIN1
RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Diseases associated with RIN1 include Bladder Urothelial Carcinoma. Among its related pathways are Vesicle-mediated transport and ErbB1 downstream signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.
Protein class
RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal respiratory cells, Basal squamous epithelial cells, Squamous epithelial cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enhanced (hTCEpi, U-2197)
Interaction
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.
Molecular function
GTPase activation
More Types Infomation
- Mouse Anti-RIN1 Recombinant Antibody (clone 1H4) (MOB-3200z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB
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For Research Use Only. Not For Clinical Use.