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RING1
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of the E2F6. com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity). Interacts with MN1 (PubMed:31839203).
Molecular function
Chromatin regulator, Repressor, Transferase
More Types Infomation
- Recombinant Mouse Anti-Human RING1 Antibody (MOB-1653MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Human, Predicted to work with: Dog, Chimpanzee, Rhesus monkey, GorillaDoes not react with Rat
- Type: IgG
- Application: IHC-P, WB, ICC/IF
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
- Mouse Anti-RING1 Recombinant Antibody (clone 8E8A2) (VS3-XY1374)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC
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For Research Use Only. Not For Clinical Use.