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RNF128

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Protein class

Enzymes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Hepatocytes, Alveolar cells type 1, Gastric mucus-secreting cells, Cholangiocytes, Distal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CAPAN-2, Hep G2, OE19, RPTEC TERT1, RT4, WM-115)

Molecular function

Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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