RNF139

Disease related genes, Enzymes, Metabolic proteins, Potential drug targets

Membrane

Group enriched (Late spermatids, Early spermatids)

Low immune cell specificity

Low cell line specificity

Interacts with MHC class I and HM13 (PubMed:19720873, PubMed:25239945). Interacts with VHL (PubMed:12032852). Component of SCAP-SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing (PubMed:19706601). Interacts with SREBF2 (via C-terminal domain) (PubMed:19706601). Interacts with SCAP; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP-SREBP complex (PubMed:19706601). Interacts with SEC24B (PubMed:19706601). Interacts with INSIG1 and INSIG2 (PubMed:20068067, PubMed:22143767). Interacts with EIF3F and EIF3H; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner (PubMed:20068067). Interacts with XBP1 isoform 1; the interaction induces ubiquitination and degradation of XBP1 isoform 1 (PubMed:25239945). Interacts with AUP1, AMFR and UBE2G2; interaction with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR/gp78, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569).

Receptor, Transferase